There are some recent human clinical studies that show it has a favorable result on the course of MS when taken in very high doses. I DO NOT RECOMMEND this high 1800 mg approach. I feel that taking a modest effective dose of a variety of things that lower MMP-9s is better. I can elaborate if asked.
jackD
Quote:
1: J Neuroimmunol 2002 Oct;131(1-2):104-14
Alpha lipoic acid inhibits T cell migration into the spinal cord and
suppresses and treats experimental autoimmune encephalomyelitis.
Marracci GH, Jones RE, McKeon GP, Bourdette DN.
Department of Neurology, Oregon Health and Science University, Portland, OR
97201, USA.
Oxidative injury may be important to the pathogenesis of multiple sclerosis
(MS). We tested the antioxidant alpha lipoic acid (ALA) in an experimental
murine model of MS, experimental autoimmune encephalomyelitis (EAE). ALA was
administered to SJL mice 7 days after immunization with proteolipid protein
(PLP) 139-151 peptide. Mice that received 5-100 mg/kg/day of ALA had
dose-dependent reductions in their 10-Day Cumulative Disease Scores (10-Day
CDS) by 23-100%. Minimal inflammation, demyelination and axonal loss
occurred in the spinal cords (SC) of ALA-suppressed mice, and there was a
marked reduction in CD3+ T cells and CD11b+ monocyte/macrophage cells within
the SC. Mice treated with ALA (100 mg/kg/day) commencing on the first day of
clinical EAE had a significant reduction in 10-Day CDS. SC of ALA-treated
mice had reduced demyelination and axonal loss and a rapid reduction in CD3+
T cells. In vitro, ALA and its reduced form, dihydrolipoic acid, inhibited
the activity of matrix metalloproteinase-9 (MMP-9) in a dose-dependent
fashion. ALA is highly effective at suppressing and treating EAE and does so
by inhibiting T cell trafficking into the SC, perhaps by acting as a matrix
metalloproteinase inhibitor.
PMID: 12458042 [PubMed - indexed for MEDLINE]
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