Very recent study on Quercetin & MS &MMP-9s and how it helps Interferon Beta treatment.

Lowering MMP-9s is GOOD for ALL folks with MS (PERIOD) regardless of DMD.

Remember folks HIGH levels of MMP-9s destroy Interferon Betas drugs.

Hope you all realize that having a nice RED apple each day is a GOOD source of Quercetin as well as the entire Onion family.

I start the day with a MOTT'S - RED DELICIOUS APPLE -Extra Fancy and real pretty from the state of Washington.

I also take a Quercetin supplement later in the day.

jackD



1: J Neuroimmunol. 2008 Oct 14.

Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients.

Sternberg Z, Chadha K, Lieberman A, Hojnacki D, Drake A, Zamboni P, Rocco P, Grazioli E, Weinstock-Guttman B, Munschauer F.
Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY, United States.

The study is aimed to determine the role of quercetin (3,3'4',5,7-pentahydroxy flavone), alone and in combination with human interferon-beta (IFN-beta), in modulating the immune response(s) of peripheral blood mononuclear cells (PBMC) isolated from multiple sclerosis (MS) patients and from normal healthy subjects.

PBMC proliferation in the presence or absence of these drugs was determined and the production of proinflammatory cytokines (IL-1beta, TNF-alpha), and the ratio of cell migration mediator MMP-9, and its inhibitor, TIMP-1 were assessed in the culture supernatants.

Quercetin reduced, in a dose-dependent manner, the proliferation of PBMC and modulated the level of IL-1beta and TNF-alpha released by PBMC in the culture supernatants.

Quercetin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production. Quercetin, when combined with IFN-beta, had additive effects in modulating TNF-alpha and MMP-9. These immunomodulatory responses to quercetin were similar between MS patients and healthy control (HC) subjects.

PMID: 18926575