I agree with Harry here.

But...I've never thought that the usual type of clinical trials will prove LDN's effectiveness beyond a doubt to anyone anyway. I mean, people are still arguing about the risks vs. benefits of the CRAB meds after a gazillion dollars worth of clinical studies. Even Mayo has doubts that the benefits are worth the risks and expense for early, mild MS patients.

I've always been skeptical about the statistical evaluation of a disease that both relapses and remits on its own, both with and without drug treatment, of patients who cannot be positively diagnosed with it, and no one quite knows what it is anyway.

So, I'm not counting on these current studies, which appear to be the beginning of about 20 years' worth of piddly little fake MS mouse trials, to convince my doctors to finally prescribe LDN for me.

When I took LDN, I found the improvements subtle, gradual, and very difficult to measure with any statistical certainty. I only know that lots of stuff felt better.

My brilliant idea has always been for some enterprising entrepreneur to recognize the potential bucks in marketing LDN as a mild supplement type of thing. They should do some wide open investigative trials on a wide variety of humans to identify exactly what effects LDN has on people, sick or not.

What easily measurable symptom does LDN help the most? Fatigue? Brain fog? Mood? Bladder problems? Heat sensitivity? For me, it worked for them all. Pick the one it does best, get it approved for that symptom, market it to the general public, and it will be available to us all, just like other inexpensive supplements.

If LDN becomes more readily available, the effects on MS progression -- if indeed there are some -- will become obvious enough to warrant a real trial.

The situation now is that, even if they finally come up with a few tiny trials that show promise, there's no way LDN will ever be proven to the extent of the big money meds and allowed to compete as an "MS med" against their marketing forces.

I personally didn't notice that LDN had any effect on my MS progression either good or bad, although I also think that progression is nigh onto impossible to measure anyway. But I do think LDN at least has the potential to save us from taking so many symptom meds.

My other idea is to convince our doctors to try a little LDN for awhile so they can see how harmless it is and feel a bit of the benefits for themselves. Hahahahaha...