The only "side effect" I experienced with LDN was when I bumped my dosage up (the first time) to 4.5 mg. I had some spasticity in my right leg so I decided to go back down to 3.0 mg. I waited about a month and tried 4.5 mg. again and have had no adverse side effects. When I went up in dosage before I was in the midst of a sinus infection and should have known better than to try to increase at that point.

I noticed benefits almost immediately when I started LDN. I could walk better, I had energy and was able to stop several meds (baclofen, neurontin and my AD).

I won't get to have another MRI until 2010 (unless something changes with my insurance) so I won't be able to compare them until then.