Sorry to be late to this thread, but I have been working alot more than usual, and just not on line long enough to research this for you.
Here is a common list of drugs/agents that have shown acne potential:
Quote:
* oral steroids
* contraceptive agents: medroxyprogesterone injection (Depo-Provera)
* oral contraceptives that reduce sex hormone binding globulin (SHBG)
* testosterone
* anabolic steroids including danazol, stanozolol
* halogens (iodes, chlorides, bromides, halothane)
* anti-epileptics (carbamazepine, phenytoin, phenobarbital)
* Anti-tuberculosis drugs (ethionamide, isoniazid, rifampicin)
* anti-depressants (lithium, amoxapine)
* cyclosporin
* B vitamins (B12, cyanocobalamin)
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There are anecdotal reports, many of them old, of cyanocobalamin reactions that look like acne, but are a specific type of lesion:
Quote:
Cutis. 1979 Aug;24(2):210-1. Links
Vitamin B-12 induced acnes.
* Dupre A,
* Albarel N,
* Bonafe JL,
* Christol B,
* Lassere J.
A type of acne induced by vitamin B-12 deserves a special place among acneiform eruptions. The eruption is monomorphic and of a particular type. It consists of voluminous folliculitis lesions which develop acutely after the first injections of vitamin B-12 and disappear rapidly when treatment is discontinued. The etiologic and pathogenic mechanisms of the disease are not know.
PMID: 157854 [PubMed - indexed for MEDLINE]
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This paper is interesting, because it does not say what megadoses were
required:
Quote:
Cutis. 1991 Aug;48(2):119-20. Links
Acneiform eruption due to "megadose" vitamins B6 and B12.
* Sherertz EF.
Department of Dermatology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Medications and other exogenous factors are known to be capable of exacerbating acne or precipitating acneiform eruptions. This case illustrates an eruption resembling acne rosacea that was temporally associated with daily ingestion of high-dose B vitamin supplement. The eruption failed to respond to the usual treatment regimens for rosacea, but promptly improved when use of the vitamin supplement was discontinued.
PMID: 1834437 [PubMed - indexed for MEDLINE]
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Most vitamin supplements do not have megadoses of B12 in them. But they typically do have cyano version.
Here is another:
Quote:
MMW Munch Med Wochenschr. 1976 Feb 6;118(6):155-60. Links
[The problem of vitamin B6/B12 acne. A contribution on acne medicamentosa (author's transl)]
[Article in German]
* Braun-Falco O,
* Lincke H.
Deterioration of acne vulgaris or eruption of an acneiform exanthema could be established during treatment with vitamin B6 and/or vitamin B12 in 14 patients. Females were by far the more frequently affected. The appearance of skin symptoms, even outside the age groups typically affected by acne vulgaris is characteristic. The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm. The pathogensis of the change is not yet certain. The acneiform rash generally fades within a short time after vitamin B6 or vitamin B12 treatment has been stopped.
PMID: 130553 [PubMed - indexed for MEDLINE]
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B6 is capable of causing a skin reaction with sun exposure:
Quote:
J Dermatol. 1996 Oct;23(10):708-9. Links
Photoallergic drug eruption due to pyridoxine hydrochloride.
* Tanaka M,
* Niizeki H,
* Shimizu S,
* Miyakawa S.
Division of Dermatology, Kawasaki Municipal Hospital, Japan.
Photoallergy to vitamin B6 is very rare; only a few cases of contact dermatitis and one case of photosensitive dermatitis due to pyritinol have been reported. We report here the first case of photoallergic drug eruption due to pyridoxine hydrochloride. A 71-year-old man developed papulo-squamous erythemata which were confined to sun-exposed sites. Photopatch testing, together with the clinical course, was helpful in reaching the initial diagnosis; this was confirmed by an oral challenge test. Photoallergic drug eruption due to vitamin B6 should be considered a rare cause of photosensitive dermatitis.
PMID: 8973037 [PubMed - indexed for MEDLINE]
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Here is an example of acne caused by inhalers containing steroids:
Quote:
Clin Exp Dermatol. 1993 Mar;18(2):148-50. Links
Acne induced by inhaled corticosteroids.
* Monk B,
* Cunliffe WJ,
* Layton AM,
* Rhodes DJ.
Department of Dermatology, Bedford Hospital, UK.
Four cases of acne apparently induced by inhalation of potent corticosteroids prescribed for the treatment of asthma are described. In one case there appeared to be a dose-dependent relationship. While acne induced by topical or systemic administration of corticosteroids is well recognized, acne following inhaled corticosteroids has not previously been reported.
PMID: 8481992 [PubMed - indexed for MEDLINE]
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All of these reports involve low numbers of patients, and a wide span of time.
Some people just cannot tolerate cyano version of B12. You know, this is a man-made product and not natural to the body.
If you suspect your acne is triggered by cyano version, you could switch to
hydroxy injection, or try the oral methyl form.
Other situations can lead to acne "attacks". Low zinc is one. Low intake of Vit A, C, E, and Selenium, also impact the skin.
Also notice in the list at the beginning of this post, that HORMONES are typically triggers. Many women today have PCOS, and the attendant elevated androgen levels, and if this is a possibility, then acne can be caused by this, or triggered by it. You can have blood tests drawn for androgens, and this will tell you if you are experiencing this effect. PCOS (polycystic ovary syndrome) is more common today than ever and being diagnosed more accurately.
Normal dosing of methylcobalamin has not appeared in the literature as causing acne, that I have found.
Lack of omega-3 in the diet, also leads to acne. My son's acne resolved with flax oil, evening primrose and fish oil daily (one capsule of each). A diet high in damaging transfats will also show up in the skin, so eliminating these harmful fats (most restaurants still use them) is important.
Since medical resources now list daily 1,000 mcg (1mg) doses of methylcobalamin as equivalent to the shots, it might be worth a trial of switching to the oral form. It only costs .09 a day.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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