Hi Cherie,

I was having continual low grade fevers from the time I had mono until I was diagnosed with MS (about 1 year and 8 months). There was a break in between at one point. My theory is that the mono may have tripped the MS switch and then the lingering fevers became just a symptom of the MS. No one could figure out what they were coming from--my rheumatologist at the time of the MS diagnosis consulted with a well known MS specialist and he said he had seen some patients with low grade fever. Even so, I just assumed it wasn't from the MS but some sort of left over chronic fatigue syndrome or post-viral syndrome from the mono. But then I went on Tysabri and a few times I would get a fever for 2 days after the infusion but the general long term fevers (usually weeks at a time, and a little higher) completely went away. It was so strange. My temp went down to below normal -- 98-98.2. It was heaven because I felt a SO MUCH better. So the little and low 2 day fever after the Ty. infusion is very different than what I had before. I have no idea what it means but it doesn't phase me since most of the time I no longer have fevers which is a godsend! I will ask my neuro next month about why I get the little fever afterward. Maybe it because of a mild over suppression of the immune system the first couple of days (higher amount of Ty. in the blood)??? But that doesn't explain much. Although, I've only had 5 infusions and I've heard you don't reach steady state medication in the body until after 6 months.

Natalie