I don't get it. And I don't have any hits on my 3 scans I do weekly either.
Here is the paper on PubMed...looks like what I quoted above.
Quote:
J Neurotrauma. 2008 Oct;25(10):1247-1256.Click here to read Links
Vitamin D(2) Potentiates Axon Regeneration.
Chabas JF, Alluin O, Rao G, Garcia S, Lavaut MN, Risso JJ, Legre R, Magalon G, Khrestchatisky M, Marqueste T, Decherchi P, Feron F.
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Université de la Méditerranée (Aix-Marseille II), Faculté de Médecine Nord, Institut Fédératif de Recherche Jean Roche (IFR11), Marseille, France., Services de Chirurgie de la Main, Chirurgie Plastique et Réparatrice des Membres, Assistance Publique, Hopitaux de Marseille, Marseille, France.
Abstract To date, the use of autograft tissue remains the "gold standard" technique for repairing transected peripheral nerves. However, the recovery is suboptimal, and neuroactive molecules are required. In the current study, we focused our attention on vitamin D, an FDA-approved molecule whose neuroprotective and neurotrophic actions are increasingly recognized. We assessed the therapeutic potential of ergocalciferol-the plant-derived form of vitamin D, named vitamin D(2)-in a rat model of peripheral nerve injury and repair. The left peroneal nerve was cut out on a length of 10 mm and immediately autografted in an inverted position. After surgery, animals were treated with ergocalciferol (100 IU/kg/day) and compared to untreated animals. Functional recovery of hindlimb was measured weekly, during 10 weeks post-surgery, using a walking track apparatus and a numerical camcorder. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. We observed that vitamin D(2) significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. In addition, functional recovery was not impaired by vitamin D supplementation. Altogether, these data indicate that vitamin D potentiates axon regeneration. Pharmacological studies with various concentrations of the two forms of vitamin D (ergocalciferol vs. cholecalciferol) are now required before recommending this molecule as a potential supplemental therapeutic approach following nerve injury.
PMID: 18986226 [PubMed - as supplied by publisher]
Related Articles
* Functional recovery after peripheral nerve injury and implantation of a collagen guide. [Biomaterials. 2008]
* Metabosensitive afferent fiber responses after peripheral nerve injury and transplantation of an acellular muscle graft in association with schwann cells. [J Neurotrauma. 2006]
* A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. [J Comp Neurol. 1991]
* ReviewTransplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury. [Prog Brain Res. 2002]
* ReviewEffectiveness and safety of vitamin D in relation to bone health. [Evid Rep Technol Assess (Full Rep). 2007]
|
Most of the paper is all about pipettes and lab protocols etc, and how the study was run actually. The only other part was the mention of only using D2 (because that is what doctors are familiar with).
Try this:
I went to the site and removed part of the url---
http://www.liebertonline.com/doi/pdf...neu.2008.0593?
This also works for me and has the "cookie" bit removed.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.