Quote:
Originally Posted by Ronhutton
Do you suffer a bad "off" immediately after a sinemet tablet wears off?
Does it gradually improve with no further sinemet over the next few hours?
After nearly18 years of PD, my off's in the mornings before I have taken any sinemet, are not too bad. I can get around. However, when a tablet wears off, I am infinitely worse, and cannot walk at all. The "relapse" gradually fades over the next 1 to 2 hours.
A very strange thing is I occassionally switch on without any sinemet. It lasts for up to an hour. However, I suffer the same relapse when the on wears off. I can't help feeling there is a big clue here. The relapse can't be blamed on toxic compounds from the levodops, I haven't had any!!!!
If any of this sounds famililiar, or any ideas, please respond.
Ron
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RON;
I think that as we rest our brains manufacture and store whatever dopamine that they are capable of manufacturing. I noted this when my left IPG's battery died. my right side was akinetic til i got up and moved around a bit. (Possibly stimulating the receptors?), Then I could move around for an hour or two. Then I got akinetic on my right side again. Unfortunately Sinemet didn't help me at all.
Charlie