I didn't start feeling better until after 3-4 doses of Tysabri. It took a lot longer to be sure the improvements were not just in my mind, so much so that I refused to post on my perceptions of how I was feeling and what I noted until after my 6 month MRI. It's been gradual and it's been steady since then.

I figure I have been diagnosed since 2004, and that it took a major event to get diagnosed, so who knows how long I was one of those silent damage people with MS who didn't know it?

Tysabri is not designed to stop relapses. It is designed to reduce the number of relapses. You may be in or coming out of relapse. There may also be some depression happening. Only you and your doc can answer that. Are you on an AD or would you consider one? Maybe talk to the doc about what you are feeling and see what his/her thoughts are about it.

I think with only one infusion under your belt, that you need to give it time to work.

Let us know what comes of this. We are rooting for you!!