I have RLS and Zofran sent me thru the roof with dystonia. The dystonia from Zofran is NOT stopped by dopamine agonists. (I got my first dose in the ER, after puking from IVIG, and they gave me a double dose.....OMG) I have had RLS my whole life and this was RLS on steroids non-stop for 10 hours.

I was on high doses of Mirapex for a good while, however, took it all at night. I was up to .675mg at bedtime for a while. Mild to moderate nausea was an issue. I was on it for 8 years or so.

Dopamine agonists have their downside, one is nausea, the other hypotension, and some folks get sleep attacks.

Generally, SSRIs (serotonin reuptake inhibitors), anticholinergics and antidopaminergics exacerbate RLS.

You may be having more RLS from coming off opiates and benzos. Been there done that, as has every one with a chronic pain issue....and yes, it is OK to walk around for a few WEEKS like a zombie. It will pass....but it stinks right now.

One caveat, we are all different.