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Member
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Join Date: Oct 2006
Location: dx'd4/01@63 Louisiana
Posts: 562
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Member
Join Date: Oct 2006
Location: dx'd4/01@63 Louisiana
Posts: 562
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I think the main evidence for assuming death of the dopaminergic neurons is the loss of tyrosine hydroxylase-positive cells in PD substantia nigra observed post-mortem, compared to normal post-mortem SN. Also, the progressive loss of dopamine re-uptake as indicated by PET and SPECT data with labeled fluorodopa and beta CIT suggests cell death.
Robert
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