First four days I got pain relief from Neutopathy. Went from 150mg to 300mg to 900 mg, and have been on it for a month now and went back to 600 mg. Now I can't sleep and pain is horrific. Tried cutting back , worsening pain. I am sold on the product, some days are good and some days are bad. Going to try 900mg now with all the following vitamins and supplements, B-complex, C, ALA,etc. I find if I do too many carbs I hurt more and if I push myself to walk, bike and use my elliptical I feel better.