I have had anxiety for many years, and had it well controlled, until...I started Copaxone. I had MASSIVE anxiety attacks during the first three months. it was awful. I was so panicked at shot time. Waiting for this one to be the IPIR. As time passed, the anxiety has softened. My dreams have calmed, and things are in a better groove. It was a rough first year, and adjusting to this stuff was enough to make me sit and suck my thumb in the corner. With time, and patience your body can adjust, and regain many of the normal habits and patterns that you were used to before Copaxone. If you are having tons of trouble, please see your MD. If its interfering with your life, then you may need half doses for a bit till you get adjusted. DONT do it without approval and guidance from your MD.