I too suffer from this disease. It is so frustrating when the levels of pain are not consistant with what you are attempting to treat them with. The rollercoaster is so demanding. You can be feeling relatively "good", and....without any warning...bam! The pain can bring you to your knees. It would be so nice if PN was like a headache. Take 2 aspirins....pain goes away. But, PN is an insidious disease. It seems to sometimes have a mind of its own. I feel for every person dealing with this malady.