Quote:
Originally Posted by mrsD
increases bleeding. For people using SSRI drugs...like Lexapro
which also increase bleeding you should consult your doctor
before using.
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also found this excerpt from wikipedia:
Vinpocetine is also a phosphodiesterase (PDE) type-1 inhibitor,[9] (with an IC50 of approximately 10-5 M.) leading to increases in intracellular levels of cyclic guanosine 3'5'-monophosphate (cGMP), an action that has been attributed to the vasorelaxant effects of vinpocetine on cerebral smooth muscle tissue.[10][11]
Increases in neuronal levels of DOPAC, a metabolic breakdown product of dopamine, have been shown to occur in striatal isolated nerve endings as a result of exposure to vinpocetine.[12] Such an effect is consistent with the biogenic pharmacology of reserpine, a structural relative of vinpocetine, which depletes catecholamine levels and may cause depression as a side-effect of the cardiovascular and anti-psychotic effects.[13]
Side-effects
Vinpocetine has been implicated in one case to induce agranulocytosis,[14] a condition in which granulocytyes - an important type of white blood cell, are markedly decreased. Some people have anecdotally noted that their continued use of vinpocetine reduces immune function. Commission E warned that vinpocetine reduced immune function and could cause apoptosis in the long term. [15]
Dosage
It is recommended that first-time users ingest only 2-5 mg of vinpocetine with meals to make sure they are not hypersensitive to it. Users may then increase the dosage to 10-40 mg a day (which may, although very rarely, cause some light side-effects).