Hi legzzalot,
Nice to meet you.

I was on Avonex for a year but my body would not tolerate it. I have flu symptoms for 5 days with fever. My Liver enzymes started to go high also.

My Neuro switched me to Copaxone which helped for about 3 1/2 and then stopped working for me. Copaxone was easy, needles are small, and I never had that bad a reaction.

Just don't inject into any area with colors, like red, blue or blackish or greenish appearing. These are veins, arteries and capillaries. You want it in the skin only with Copaxone. With Avonex you dart it straight down to the muscle, that is why the needle is thicker and longer.

If you want an opinion I would say start on Avonex if you plan to do Rebif in the future. As said above, Rebif is twice the dosage of Avonex. If it agrees with you, and it does work for many people, without getting fluish, then you know you will be able to switch later on to a stronger dosage.

With Avonex and Rebif it is best to start with 1/4 of the shot amount and work your way up to full dosage.

Copaxone you don't do it that way. You take the full dosage daily, everyday. Both are easy to do.

If you try Avonex, do you have to do Copaxone before you can do Rebif? That sounds odd to me. Good luck with whatever you decide to try. You can always switch around.
Lady