Are you referring to the Zetia? There is some risk, but not as high as it would be for Lipitor. It would be best to get a
CPK test about 3-6mons after starting Zetia, to see if it is affecting it.

Personally I think certain people are more at risk to CPK elevations than others. With the research into mitochondrial damage becoming more complete...we see mito issues with vaccine damage in autism now as well. The thought is that some people have recessive genes for mitochondrial disorders and only express damage when a big thing (drug/vaccine/illness) comes along to set it off. I read a paper a long time ago (about 10 yrs ago) stating that many people have recessive genes for mito disorders and begin expressing them when they get older (over 40-50).

There are many drugs that damage mitochondria.

http://www.rsc.org/chemistryworld/Ne...y/25020801.asp

http://www.mail-archive.com/sustaina.../msg73462.html

With all the reading I do online, and searching...it seems we always come back to this: mito damage.

In fact Dr. Bruce Ames believes that mito damage of simple aging can be diminished with certain nutrients:

http://www.bruceames.org/

So it is possible your husband has a genetic predisposition to
mito damage. I sure know MY doctor argues with me about this all the time. This week she said she takes 20mg Lipitor herself with no problem. And my response to that? Good for you, but you are NOT me! I don't want to take that risk right now. (I couldn't really tell her that she is not as sharp as she once was, either! but she isn't, and I think Lipitor is HER problem.)