Quote:
Drugs R D. 2008;9(4):243-50.Links
Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study.
Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N.
Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India.
BACKGROUND AND OBJECTIVE: Hyperglycaemia leads to increased oxidative stress resulting in endothelial dysfunction. ACE inhibitors, antioxidants and HMG-CoA reductase inhibitors (statins) have been shown to improve endothelial function. The aim of this study was to compare the effects of NCB-02 (a standardized preparation of curcuminoids), atorvastatin and placebo on endothelial function and its biomarkers in patients with type 2 diabetes mellitus. METHODS: A total of 72 patients with type 2 diabetes were randomized to receive NCB-02 (two capsules containing curcumin 150 mg twice daily), atorvastatin 10 mg once daily or placebo for 8 weeks. Endothelial function assessment was performed at baseline and post-treatment using digital volume plethysmography (salbutamol [albuterol] challenge test) to measure change in reflective index, an indicator of arterial vascular tone. Blood samples were similarly collected at baseline and post-treatment for estimations of malondialdehyde, endothelin-1 (ET-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFalpha). Pre-and post-treatment safety assessments were also conducted. ANOVA and paired t-test evaluations were used for comparison. RESULTS: A total of 67 patients completed the study. At baseline, there was no significant difference in the various parameters tested. In all three groups, the change in reflective index at baseline was <6% as assessed by the salbutamol challenge test, indicating the presence of endothelial dysfunction. Compared with baseline, there was a significant improvement in endothelial function after treatment with atorvastatin (mean +/- SD: -3.63 +/- 3.17% vs -8.95 +/- 6.80%, respectively) and NCB-02 (-2.69 +/- 3.02% vs -8.19 +/- 5.73%, respectively). Similarly, patients receiving atorvastatin or NCB-02 showed significant reductions in the levels of malondialdehyde, ET-1, IL-6 and TNFalpha. No significant improvements were obtained in patients administered placebo. CONCLUSION: NCB-02 had a favourable effect, comparable to that of atorvastatin, on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress. Further studies are needed to evaluate the potential long-term effects of NCB-02 and its combination with other herbal antioxidants.
PMID: 18588355 [PubMed - indexed for MEDLINE
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Given that Lipitor's actions are now being thought to be more helpful with this factor than the cholesterol lowering
the curcumin effects are very promising.
Here is another: on GI inflammation:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
I am trying to find the preparation used for the studies
NCB-02...
I found this as far as dose..
http://www.ingentaconnect.com/conten...00004/art00004
But I wonder if an enhancing substance is included in the prep?
Anyone know?
I just found this:
http://www.lef.org/magazine/mag2007/...urcumin_01.htm
(without piperine)
and here it is:
http://www.epic4health.com/cuenbicu.html
I've been using Curcumin for almost a month, for my arthritis. (I stopped my SAMe for comparison)
So far so good. I have not had a relapse which I typically did when I tried to stop SAMe in the past.
I am interested in the endothelial actions of curcumin for myself, to perhaps lower
C-reactive protein, which I will have tested in 3 months. I am going to try this version I just
found! I have used Epic4health before. Their carnitine fumarate was helpful to me in the
past. So I know they are a reliable company. I do not see Bioperine listed as an ingredient!
I just found a double strength 500mg curcumin gel at the above website...and ordered 2 of them!
That is a 4 months supply for me, and came to $49.00. Not bad!
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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