I am not sure how I stumbled upon this concept, and there is not a lot in layman's terms, however, apparently having a mutation (polymorphism) in the drug metabolism enzyme CYP 2D6, is associated not only with drug problems but also with spondyloarthropathies and a few other diseases. It seems most connected in spondyloarthropathies.

Anyway, any one who has issues with medications would be well served to read up on the inability of some folks to metabolize medications. This also may extend to substances in the environment, but not much research has been done yet on this.

I know some PNers have arthritic issues, and I wonder how much overlay there is. Maybe some one can explain this better, as I am in territory that is getting a bit over my head, and I don't know how this relates to debrisoquine hydroxylase deficiency...any chemists, pharmacists or really smart people who can explain is a debrisoquine hydroxylase deficiency the reason that the drugs can't be tolerated, or is it that you can't tolerate debrisoquine hydroxylase?? And, how and why should this be associated with diseases such as Ankylosing Spondylitis?

I really need some answers, because, I am soooo sick of getting sick on this list of drugs, and getting very little relief from the pain med mentioned...and I am wondering why every joint in my body is sore, (enthesitis or enthesopathy) and what this has to do with neuropathy??? Did I get a boatload of bad genes or is this one systemic condition?? I am getting to the end of the internet...again.

BTW, IVIG is helping the neuropathy, a lot...but not the arthropathy, arthritis or other issues.

http://www.fpnotebook.com/Pharm/Meta...02d6Isnzym.htm