Ten percent of Caucasians have a gene mutation that does not allow them to metabolize serotonin re-uptake inhibitors. I am one of them. I see a few other people can not take them either.

Docs make the assumption that serotonin always needs to be increased.

I check the Cytochrome P450 chart and if it is metabolized by the 2D6 family of enzymes, I don't take the drug. I have been sick too many times.

I am on the least amount of medication in a long time, and I feel OK. I am still sick but now I know when I am sick from disease versus meds. Sort thru your meds, and decide what you have to have...keep that...what you feel you don't need, talk to your doc about stopping.

Everything we stick in our body affects us....even stuff on our skin. My husband can take anything....he took benadryl yesterday to stop sneezing and fell asleep for a few hours like a baby....I take benadryl and tic and twist for 3 days and nights solid. We are all different. Someday they will be able to do our pharmacological blueprint before they prescribe.