All I know is that my neuro has recommended Azilect and I am already on Mirapex (.5 mg 4Xday - similar to Requip) and Sinemet (1.5mg 4Xday) - I've had PD about 5 years. I've been putting off Azilect as I hate to add more chemicals and I anticipate an adjustment period, but maybe it would be helpful? I don't think there is any evidence of slowing progression beyond the very early stages, but, realistically, they probably couldn't tell yet.

Sasha