How long have you been on LDN now, Marion . . . (if you happen to get this message)? You really have had some great improvements, haven't you? I can't recall if your improvements were fairly sudden after starting, or if it took some time before you no longer needed the wheelchair, etc. . .?

Like you said, "we still have MS", and it seems that MonSter will rear its ugly head to remind us if we get too cocky. I'm going on 4 yrs now, and I am still hesitant to give LDN all the credit it is due (in my case).

I agree Desinie . . . you have double protection now. If I didn't have such difficulty with drugs, and almost entirely spinal lesions (this far into the disease process), I think I would be on Copaxone too. Additionally, that is.

Lady, you know your progression rate over the years, and perhaps this is where you might ultimately see the most benefit. I was in a bad way, and going downhill FAST, especially in the last two years before LDN. More then anything I wanted to SLOW the beast!! I got more then I bargained (and paid ) for, but I realize I was very fortunate in that regard.

As far as that "flush" or "rush", does it last about 30 min? I had that, but it stopped after the first several nights of a new dosage. Glad you've found the trick for you is to stay up for a little bit.

Also, did you always wake during the night (morning )? You said you sleep about 10 hrs, but wake often for bathroom, etc. breaks. Is this new?

LDN seems to work somewhat differently for everyone (guess that's true for many drugs), but as long as you are open to adjusting around the initial side-effects, it pays off most times.

Cherie