for 9 years for my arthritis and joint pain.
I have just stopped it, as an experiment, since I am now trying a new curcumin product called Curcu-gel 500mg. This product was developed to increase the absorption of curcumin, which has a low level when used as an herbal extract.
So far so good. I have not relapsed as I have in the past when I tried to stop the SAMe.
There are more studies now on PubMed about curcumin and inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
And this --a comparison to Lipitor!
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
Quote:
|
ondialdehyde, ET-1, IL-6 and TNFalpha. No significant improvements were obtained in patients administered placebo. CONCLUSION: NCB-02 had a favourable effect, comparable to that of atorvastatin, on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress. Further studies are needed to evaluate the potential long-term effects of NCB-02 and its combination with other herbal antioxidants.
|
The curcumin in Zyflamend is not the enhanced absorption type.
One thing I do see is that the amount of each ingredient is rather low. Ginger for example when used as an antioxidant is used in 500mg doses. And the HuZang is low too. You can buy this and get so much more:
http://www.iherb.com/ProductDetails....621087047&at=0
I've been trying to drink some red wine to get the benefits of Resveratrol--which are really exciting in the new studies.
example:
Quote:
Biochem Pharmacol. 2008 Dec 3. [Epub ahead of print]Click here to read Links
Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats.
Rivera L, Morón R, Zarzuelo A, Galisteo M.
Department of Pharmacology, CIBER-EHD, CTS-164 Research Group, School of Pharmacy, University of Granada, Campus Universitario Cartuja s/n, 18071 Granada, Spain.
Resveratrol is a natural polyphenolic stilbene derivative found in several human diet components that possess important and wide-ranging effects in biological systems including anticancer, anti-inflammatory, antioxidant, cardio-protective, and anti-ageing actions and beneficial properties against metabolic diseases. This study addresses the effects of long-term administration of resveratrol on several functional alterations arising from the metabolic syndrome experimental model of obese Zucker rats, and the possible mechanisms involved. The high plasma concentrations of triglycerides, total cholesterol, free fatty acids, insulin and leptin found in obese Zucker rats were reduced in obese rats that received resveratrol. Furthermore, the elevated hepatic lipid content was significantly lower in obese rats treated with resveratrol, an effect which was related to the increased phosphorylation of 5'-AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in the liver of these animals. Resveratrol treatment also improved the inflammatory status peculiar to this model, as it increased the concentration of adiponectin and lowered tumor necrosis factor-alpha production in the visceral adipose tissue (VAT) of obese Zucker rats. Moreover, chronic intake of resveratrol enhanced VAT eNOS expression among obese Zucker rats. These effects parallel the activation of AMPK and inhibition by phosphorylation of ACC in this tissue. The raised systolic blood pressure and reduced aortic eNOS expression found in obese Zucker rats were significantly improved in the resveratrol-treated obese rats. In conclusion, resveratrol improved dyslipidemia, hyperinsulinemia, hyperleptinemia and hypertension in obese Zucker rats, and produced anti-inflammatory effects in VAT, effects that seem to be mediated by AMPK activation.
PMID: 19100718 [PubMed - as supplied by publisher]
|
I can't seem to tolerate the sulfites in the wine and the headache I get from red wine..so I found this supplement instead from NOW. I think it is so much better than the small amount in Zyflamend.
I see that Zyflamend is advertising alot lately. That supplement is not new you know. There are reviews about it from 2004 on some sellers. When my Iherb order was delivered yesterday, it had Zyflamend samples included!
Zyflamend is one of those combination products with alot of ingredients. When that is done, there typically can be not enough of some of the more valuable ones ...like the reseveratrol and curcumin.
I prefer to use the potent forms of the curcumin and reseveratrol that were used in the studies.
example:
http://www.epic4health.com/cuul500mgena.html
SAMe was wonderful for me. I avoided a knee replacement surgery by using 600mg each morning on an empty stomach.
It improves mood and liver function too. The doctor predicted my left knee would "go" in 5 yrs, and that was 4 yrs ago..and it has not. I think if you have some cartilage left, you may be able to rebuild it with SAMe. It is not a FAST fix, but it does work over time. Studies have shown it comparable to Celebrex after 3 months use.
If you choose Zyflamend... take a look at iherb's prices. They tend to be lower than other places.
Let us know how it works for you.
P.S. If you go to iherb there are alot of reviews about this product:
http://www.iherb.com/ProductDetails.aspx?pid=77&at=0
Start at the last page and work forward... there are mixed reviews there.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.