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In Remembrance
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Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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In Remembrance
Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
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Vitamin D and the immune system:
Vitamin D and the immune system: role in protection against bacterial infection.
http://tinyurl.com/6uf5tr
Bikle DD.
Veterans Affairs Medical Center, San Francisco, California 94121, USA. Daniel.bikle@ucsf.edu
PURPOSE OF REVIEW: The role of vitamin D extends well beyond that of regulating calcium homeostasis. One of these areas is immune function. Immunity is both adaptive and innate, and vitamin D signaling is operative in both. This review will examine these actions of vitamin D, in particular the role of vitamin D in host defense against infection. RECENT FINDINGS: This review will consider two examples of vitamin D-regulated innate immunity that have been recently explored: the role of vitamin D signaling within macrophages to enable them to respond to and kill Mycobacterium tuberculosis organisms, and the role of vitamin D signaling in the keratinocytes of the epidermis to enable them to respond to disruption of their barrier function. Potential application to periodontal disease will then be considered. SUMMARY: Both adaptive and innate immune processes are two edged: beneficial and harmful. Although suppression of adaptive immunity may be beneficial in a number of self-destructive diseases, such suppression may predispose to infection. Enhancement of innate immunity is clearly beneficial in diseases like tuberculosis, but potentiation of proinflammatory processes can increase tissue destruction as in bone loss in periodontal disease. The balance, however, favors adequate vitamin D nutrition in host defense against infection.
PMID: 18660668 [PubMed - indexed for MEDLINE]
Related ArticlesReview The noncalciotropic actions of vitamin D: recent clinical developments. [Curr Opin Nephrol Hypertens. 2008]
ReviewVitamin D in defense of the human immune response. [Ann N Y Acad Sci. 2007] ReviewVitamin D and innate immunity. [Curr Opin Investig Drugs. 2008]
ReviewVitamin d and its role in cancer and immunity: a prescription for sunlight. [Nutr Clin Pract. 2007]
ReviewThe complex role of vitamin D in autoimmune diseases. [Scand J Immunol. 2008] » See Reviews... | » See All...
http://tinyurl.com/6uf5tr
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with much love,
lou_lou
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by
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, on Flickr
pd documentary - part 2 and 3
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Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.
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