All of the latest "solutions" have issues for some of us. For me Lyrica did reduce the pain BUT, my hair began to fall out - significantly. Had (some say "chose") to stop the Lyrica. Neurontin also reduced pain but increased weight - significantly (30-40 lbs) - already carrying 25 xtra lbs so this too was discontinued. Now comes Cymbalta, the latest "cure" A quick search of the posts I've made today will tell you about that less than positive experience! No pain reduction & rather than reducing depression sympts it created aggitation & anxiety instead! Not pleasant. For me: Ultram 100mg/12 hrs continues to work after 5 years!!

~ K