I lost most of my sense of smell about 20-25 years ago - a good 15-20 years before my diagnosis. My husband & I compared our answers on the sniff test - - surprisingly (to me) we agreed about 75% of the time.

They also took lots of my husband's blood to check for Alpha-synucleins and other things that might prove to be biomarkers.

If they identify family members of pwp who are losing their sense of smell, then why not send them to Yale for SPECT DAT scans? This has great promise to be a diagnostic tool for PD.

At a recent seminar, my husband asked the Neurologist from Mayo - "what good is it to identify people with very early PD?" The reply was - "so we can test possible neuroprotective treatments on them -- it may be that by the time people are diagnosed, it's too late for some of these treatments to work. And that's why they may be failing in clinical trials"

something to think about