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Old 01-24-2009, 07:42 AM
glenntaj glenntaj is offline
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Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default It's good that you've had that extensive a lab work-up--

--and that most of the results fall into "normal" ranges.

The presumption is that your autoimmune processes, which you do have evidence for--the elevated ANA, scleroderma, thyroid nodules--are the cause of your neuropathy, and certainly any of the ANA autoimmune vasculitic/connective tissue disorders can cause nerve compromise. (And, low thyroid function is also implicated in neuropathy). I wonder, though, if it might be worth it at some point to get titred up for some of the specific anti-nerve autoantibodies--anti-sulfatide, anti-myelin associated glycoprotein, and the like. If any of these were present it might suggest a somewhat different immune modulating regimen.

In the Useful Website stickies you can see good lists of these autoantibodies in the Quest/Latov paper:

http://www.questdiagnostics.com/hcp/...eralNeurop.htm

and also in the Liza Jane spreadsheets:

http://www.lizajane.org/NeuronalAntibodyTests.htm

as well as at the Washington University at St Louis. Neuromuscular website:

http://neuromuscular.wustl.edu/nother/autoantibody.html
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