is an aromatase inhibitor. Not much is understood about this class of drugs.
While this study does not address Zonegran...it does address the issue, that little is understood about this class of drugs.
http://erc.endocrinology-journals.or...nt/6/2/181.pdf
Liver-wise... Arimidex inhibits an enzyme in the liver...which MAY affect (raise)
Zonegran levels...however, you are seeing the reverse.. a potential LOWERING of levels.
http://www.cancercare.on.ca/pdfdrugs/Anastrozole.pdf
So this is confusing.
Quote:
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Metabolism and Excretion: Following oral administration of 14C-zonisamide to healthy volunteers, only zonisamide was detected in plasma. Zonisamide is excreted primarily in urine as parent drug and as the glucuronide of a metabolite. Following multiple dosing, 62% of the 14C dose was recovered in the urine, with 3% in the feces by day 10. Zonisamide undergoes acetylation to form N-acetyl zonisamide and reduction to form the open ring metabolite, 2-sulfamoylacetyl phenol (SMAP). Of the excreted dose, 35% was recovered as zonisamide, 15% as N-acetyl zonisamide, and 50% as the glucuronide of SMAP. Reduction of zonisamide to SMAP is mediated by cytochrome P450 isozyme 3A4 (CYP3A4). Zonisamide does not induce its own metabolism. Plasma clearance of zonisamide is approximately 0.30-0.35 mL/min/kg in patients not receiving enzyme-inducing antiepilepsy drugs (AEDs). The clearance of zonisamide is increased to 0.5 mL/min/kg in patients concurrently on enzyme-inducing AEDs.
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I suspect this is where the problem lies. Only the liver enzyme systems are extremely complex. You could call the company and ask them!
There is a survey for side effects from Arimidex...
http://www.bcaction.org/Pages/TakeAc...tionnaire.html
I can't see how the gluten free diet would affect Arimidex. The estrogen connection is interesting...did you have seizures connected to your periods, before? That might be a clue of sorts. The Arimidex is a huge unknown, and
many years are typical in the realm of side effects. Many don't get reported, and it takes a LONG time to understand actions of a new drug. Especially this one which is a whole NEW CLASS of drug besides!
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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