Amy, I would get copies of all your MRI's, your LP report, including all other reports, tests and blood work you have had in the past few years.

I would bring them to both a Rheumatologist and a MS Specialist, perhaps both specialties in a large well known teaching hospital in your area.

I, too, have positive antibodies for Lupus and a few Lupus symptoms, but I did not meet the criteria for Lupus. My ANA count is 1:640. It may go down to 1:320 which is only one test different from the other higher number. Normal is 1:40 Next is 1:80 low positive. It doubles with each test they do on it. It only sounds high.

My MS Specialist said many people with MS have a positive ANA. As for Sjogren's that too must have more tests done to confirm it by a Rheumatologist.

As for spots on the brain, you can have many and not have any disability at all or any bad symptoms. Then you may have only one or two spots and have disability. It is all location, location, location.. in the brain.

Also it is the size of the lesions, and if they are active (bright spots) or have turned to scars or dark holes. Some heal and remyelinate.

Amy see these doctors for second opinions and find out for sure what you dx is. You could have more than one. Multiple Autoimmune dx's are not uncommon. I have a few myself. Lupus they always try to throw into my mix, but so far I don't have it.

There are lots of blood tests you need to get. Good Luck on your road Amy.