Our neuro told us that the sinemet is cumulative, that's why my husband's early doses don't last as long as his ones in the afternoon. He said the sinement builds up in the system and so the latter part of the day is when he has most levodopa in his brain.

Also, if he eats ANYTHING it really disrupts things. Some days, a lot of them, actually, he will go into "snake mode", where he will not eat anything all day (horrible for blood sugar but he'd rather be able to function) and then eat an entire day's worth of food at night. We talked to our neuro who said this was a terrible way to deal with things, he could never imagine doing that since he obviously likes to eat (and a lot, I might add). But what can you do.

On curcumin, does that stuff give anyone a stomach ache? Did it go away after awhile, or do you get the bellyache every time you take it? Thanks.