is over 30 yrs old.

Initially it was because of a hard to diagnose thyroid condition.
Once that got the proper attention, my feet and hands improved somewhat (about 80%). At one point I could not sign my name. I had a power of attorney for my husband to use in my behalf. My very first supplement was P5P over a decade ago. This one was pretty dramatic in giving me improvement, esp in my hands. I don't wear the braces anymore unless I overdo gardening. Some days it is hard knowing what is too much. So my husband helps with the heavy digging now. I managed to continue to work, and be on my feet up to 13 hrs a day. (no sitting in my job).

Then I became OLDER...and then it was insulin resistance that started in. This was burning, and sometimes stabbing twinges.

I have no real progression today, and many low pain or no pain days. I do not use drugs except for Tylenol or Aleve OTC.
I have found several supplements that work for me. It was slow going, some trial and error. I have some food triggers, that took me years to figure out. Since I eliminated potatoes at night, and MSG and all sugar/fructose my burning has been much better with fewer flares. I did gluten free for about 3 yrs, but did not see nearly the improvement that fructose free gave me.

Everyone is different, genetically.