It might be worth noting that not all of us respond to generic Sinemet - I have no reaction at all to the generic, but the "real stuff" is very helpful (and expensive). Leads me to wonder how many have been given the generic as a diagnostic tool....personally, all I had to do was walk down the hall and the MDS said "Parkinson's." I could have wished for something diagnostically more "scientific" seeming, but, as the MDS said, it beat ALS (the other diagnostic candidate in my case).