what was painful the injection of the needle(might be set too deep if using autoinject) or the medicine itself, I use the auto also cause I am a whimp, self injected a few times I can do it if need be, but I have to watch the depth settings on mine cause occasionally it is set too deep and i hit something and it hurts like you know what. I sure hope the pains ease up and you are able to inject without any problems. my only other suggestion which sure was mentioned make sure its warm room temp b4 injecting