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Old 02-08-2009, 03:09 PM
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olsen olsen is offline
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Join Date: Aug 2006
Posts: 1,860
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Default statins and muscle problems

There have been a number of studies validating that myalgias and other muscle problems CAN develop from statin use without elevation of CPK...the article below is one that notes significant myopathy identified from muscle biopsy without an increased plasma CPK.
You may want to search "statins" or "lipitor" for all the sites on Neurotalk--peripheral neuropathy, parkinson's, ALS, etc. http://www.annals.org/cgi/content/abstract/137/7/581

Annals of Internal Medicine
Statin-Associated Myopathy with Normal Creatine Kinase Levels
Paul S. Phillips, MD; Richard H. Haas, MD; Sergei Bannykh, MD, PhD; Stephanie Hathaway, RN; Nancy L. Gray, RN; Bruce J. Kimura, MD; Georgirene D. Vladutiu, PhD; John D.F. England, MD, the Scripps Mercy Clinical Research Center*

1 October 2002 | Volume 137 Issue 7 | Pages 581-585
Results: All four patients repeatedly distinguished blinded statin therapy from placebo. Strength testing confirmed weakness during statin therapy that reversed during placebo use. Muscle biopsies showed evidence of mitochondrial dysfunction, including abnormally increased lipid stores, fibers that did not stain for cytochrome oxidase activity, and ragged red fibers. These findings reversed in the three patients who had repeated biopsy when they were not receiving statins. Creatine kinase levels were normal in all four patients despite the presence of significant myopathy.
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