could you please PM me that information?
This is the other thread where we discussed this problem:
http://neurotalk.psychcentral.com/sh...light=poligrip
I searched again today, and found mostly lawyer sites with the original article on them repeated over and over.
There is this new anecdotal report on PubMed:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
And this paper..
Quote:
Neurology. 2008 Aug 26;71(9):639-43. Epub 2008 Jun 4.Click here to read Links
Comment in:
Neurology. 2008 Aug 26;71(9):622-3.
Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease.
Nations SP, Boyer PJ, Love LA, Burritt MF, Butz JA, Wolfe GI, Hynan LS, Reisch J, Trivedi JR.
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8897, USA. sharon.nations@utsouthwestern.edu
BACKGROUND: Chronic, excess zinc intake can result in copper deficiency and profound neurologic disease. However, when hyperzincemia is identified, the source often remains elusive. We identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremia and hyperzincemia. Each of these patients wore dentures and used very large amounts of denture cream chronically. OBJECTIVE: To determine zinc concentration in the denture creams used by the patients as a possible source of excess zinc ingestion. METHODS: Detailed clinical and laboratory data for each patient were compiled. Tubes of denture adhesives were analyzed for zinc content using dynamic reaction cell-inductively coupled plasma-mass spectrometry. Patients received copper supplementation. Copper and zinc levels were obtained post-treatment at varying intervals. RESULTS: Zinc concentrations ranging from about 17,000 to 34,000 mug/g were identified in Fixodent and Poli-Grip denture creams. Serum zinc levels improved in three patients following cessation of denture cream use. Copper supplementation resulted in mild neurologic improvement in two patients who stopped using denture cream. No alternative source of excess zinc ingestion or explanation for hypocupremia was identified. CONCLUSION: Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease.
PMID: 18525032 [PubMed - indexed for MEDLINE]
Related Articles
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from
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
Looks like Poligrip has changed!
http://www.poligrip.com/whatsnew.aspx
You know I recall reading when this happened that the man who had the severe poisoning was EATING the Poligrip...
He liked the taste and was eating it besides using it as an adhesive.
There is this interesting article from 2003--before the first poisoning reports:
Quote:
Arch Neurol. 2003 Sep;60(9):1303-6.Click here to read Links
Comment in:
Arch Neurol. 2004 Apr;61(4):604-5; author reply 605.
Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome.
Hedera P, Fink JK, Bockenstedt PL, Brewer GJ.
Department of Neurology, University of Michigan, Ann Arbor, USA. peter.hedera@vanderbilt.edu
OBJECTIVE: To describe a patient with idiopathic zinc overload without an identifiable source and secondary copper deficiency causing myelopolyneuropathy and pancytopenia. DESIGN: Case report. PATIENT AND RESULTS: A 46-year-old man presented with severe bone marrow suppression and subsequently developed progressive myelopathy with sensory ataxia. No identifiable cause of myelopathy was detected, and his neuroimaging findings were unremarkable. Plasma analysis demonstrated a low copper level and an increased zinc level (<10 micro g/dL [<12.6-18.9 micro mol/L] and 184 micro g/dL [28.2 micro mol/L], respectively; normal range for both, 80-120 micro g/dL [12.6-18.9 micro mol/L and 12.3-18.4 micro mol/L, respectively) and a low level of ceruloplasmin. There was no evidence for an external source of zinc. Daily oral supplementation with 2 mg resulted in the prompt reversal of hematologic abnormalities, improved but still subnormal plasma copper levels, and normalization of ceruloplasmin values. The patient's neurologic condition deteriorated further, with worsening of myelopathy and development of polyneuropathy. Analyses of plasma copper and zinc levels demonstrated persisting hyperzincemia and subnormal copper levels during 4 years of follow-up. Increased copper supplementation to 8 mg/d partially reversed his neurologic signs. A clinical investigation of 6 siblings and 1 surviving parent did not identify family members with similar abnormalities. CONCLUSIONS: Persistent hyperzincemia without an identifiable external source appears to be a primary metabolic defect, while copper deficiency is a secondary phenomenon, causing hematologic and neurologic abnormalities. Two unrelated patients with similar idiopathic hyperzincemia and hypocupremia have been recently described. This suggests the existence of a new metabolic disorder with idiopathic zinc overload.
PMID: 12975299 [PubMed - indexed for MEDLINE]
Related Articles
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from http://www.ncbi.nlm.nih.gov/pubmed/12975299?ordinalpos=1&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.P ubmed_Discovery_RA&linkpos=1&log$=relatedarticles& logdbfrom=pubmed
So if there IS a zinc overload disorder (similar to iron overload--hemachromotosis) then that may explain things. But then maybe this 2003 report reflects denture cream, which was NOT considered?
I really wonder if Poligrip is manufactured in China FOR Glaxo?
I might call their toll free number to clarify that later today.
Most of Glaxo products are made in other countries.
I found this plant (which may be the ONLY one)
http://www.pharmaceutical-technology...jects/zebulon/
And it looks like the Zebulon plant is being reduced or phased out.
http://localtechwire.com/business/lo...story/2438435/
http://localtechwire.com/business/lo...story/2501033/
http://us.gsk.com/html/career/career...ss-global.html
Here is an interesting article about zinc ions and "colds".
http://www.coldcure.com/html/hand_3.html
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Weezie looking at petunias 8.25.2017
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