Based upon my experience, all should set aside any stigmas attached to the use of Methadone to take advantage of it's unique properties in the battle against neuropathic pain. As most know, opiods are not very effective for controlling the large amouts of pain associated with RSD and even when getting on very large doses, the pain management is usually only adequate at best for a limited period of time. Methadone is unique in that while it is a narcotic and provides pain relief, it also effects the NMDA receptor of the brain, currently believed to be one of the major receptors, thus enablers, of neuropathic pain. This is why KETAMINE is so popular for the treatment of RSD, 'cause it is a strong blocker of the NMDA receptor as a primary mechanism of action. So, for those who are looking at Ketamine but are worried about the stigma of Methadone, look towards this cheaper alternative that is more available and for which doctors understand more and are more open to the real uses. Methadone is one of the most studied drugs around and despite the current abuses making things difficult for patients (as usual) it remains a great weapon against pain.