Hi Cherie,

I've had winter depression for about the last 5-6 years so I don't think it has anything to do with the Tysabri. It's actually not as bad this year because I haven't had to increase my Cymbalta yet. If I just get myself up and moving that seems to help. I just needed someone to give me a little nudge to do it though. I seem to fall into a self-pity mode this time of year and if I look at it objectively I can deal with it ok. The neuro helped me to do that this time.