Originally Posted by Natalie8

Funny you should mention this. I believe the Tysabri has exacerbated my depression. I've struggled with depression for almost 2 decades so I'm very attuned to any shift or change in my mood. I was doing fine and stable but I've noticed creeping depression since I've been on the drug. I don't want to go off Ty. and I cannot increase the dose of the AD's I am on (I am so drug sensitive it's a miracle I've found drugs I can tolerate). So I've started taking fish oil which has helped a lot (this surprised me!). Now I just need to get my lazy butt to the gym! Exercise helps just as well as AD's, at least in my case. After one infusion, it was particularly bad and scary--a sort of super wave of heavy black depression that seemed to come out of nowhere but the really bad stuff let up after a few days. In general, though, I'd say it has had an effect on my mood that I'm not really happy about (no pun intended!)