I think the price increase is awful. Not just a few bucks, but hundreds. I am sure people's Medical Insurance companies will have to make pricing deals or pay the increase.
Avonex and Rebif are recombinant interferons that are produced in cell cultures. Maybe they are running out of the Red Chinese hamster ovaries to make it in.

Betaseron is a modified interferon beta. It is made by recombinant DNA and purified from bacteria. Copaxone is made from four synthetic amino acids (proteins) in a random chain. Each shot has 22 mgs of G, L, A and T (
Glatiramer acetate) with 40 mgs of Mannitol.
Ty and other MS drugs, I haven't a clue how or what they are made of, I never studied them because I never tried them.
I guess the laboratories that make these drugs are having increases of some nature, to cause the increase. I don't know if it's supply and demand, new research costs for other drugs, or the economy in general. I am not that smart, or I would be rich instead of just making ends meet.