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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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A lot there to digest
But it is heartening to see neuroendocrinology having some bold input.
The way that I read it, melatonin is actually a problem in PD and should be avoided. There had been hints of this for years. An early therapy for PD was sleep deprivation which lowered melatonin production.
I become more and more convinced that the endocrine system is the Big Dog here and not the nervous. The latter has a very limited number of factors to account for a large number of symptoms. "OK, ya got dopamine. What else?"
The endocrine system, however, has hormone squirting out of everything but the ears. Cortisol, epinephrine, insulin, estrogen, testosterone, and a half-dozen more. And every one of them has receptors in the brain. You can explain a lot of non-motor symptoms with that kind of toolkit.
The heartening thing to me is that with a rich, complex collection of causes there are a rich, complex set of opportunities to intervene.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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