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Old 03-09-2009, 08:44 PM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

There are many reports of B12/nitrous problems like this:

Quote:
Rev Neurol (Paris). 2007 Mar;163(3):362-4.Click here to read Links
[Nitric-oxide triggered neurological disorders in subjects with vitamin B12 deficiency]
[Article in French]

Cohen Aubart F, Sedel F, Vicart S, Lyon-Caen O, Fontaine B.

Assistance Publique-Hôpitaux de Paris, Fédération des maladies du Système Nerveux, et Université Pierre et Marie Curie, Groupe Hospitalier Pitié Salpêtrière 47-83 boulevard de l'hôpital 75013 Paris, France.

INTRODUCTION: Nitrous oxide is frequently used for anesthesia. It may cause spinal cord toxicity. CASE REPORTS: We report two patients who presented gait disorders after nitrous oxide anesthesia. Physical examination revealed arms and legs pyramidal syndrome and abnormal proprioception, consistent with subacute combined degeneration of the spinal cord. Serum vitamin B12 level was extremely low. The patients improved with parenteral treatment with hydroxycobalamin. CONCLUSIONS: The inactivation of methionine synthase and L methylmalonylcoA mutase by nitrous oxide has been previously demonstrated. Anesthesia-related exposure to nitrous oxide may induce neurologic disorders even in patients with no preliminary vitamin B12 deficiency.

PMID: 17404524 [PubMed - indexed for MEDLINE]
from http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

If you click on the PubMed link at the top right of the page here, and then type into the keyword search:
vitamin B12 nitrous oxide

you'll find many more papers.
From what I saw tonight, this effect is more pronounced in people who are marginally low in B12.

I suspect your once a month injection was not enough for you in the first place. Do you know what your level was then?
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