Thread: Migraine Mice Exhibit Enhanced Excitatory Transmission At Cortical Synapses
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Old 03-12-2009, 01:38 PM
Jaspar Jaspar is offline
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Join Date: Oct 2008
Posts: 290
15 yr Member
Jaspar Jaspar is offline
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Join Date: Oct 2008
Posts: 290
15 yr Member
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calcium influx and subsequent glutamate release at cortical pyramidal cell synapses were increased in mice carrying the FHM mutation. Glutamate is the major excitatory neurotransmitter in the brain. The facilitation of induction and propagation of CSD in the FHM mice was completely eliminated when glutamate release was decreased to control levels. Importantly, in contrast with the enhanced excitatory neurotransmission, inhibitory neurotransmission was not altered in the migraine mice.
This further blurs the line between neurology and psychiatry.
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