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Old 03-16-2009, 09:43 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Methadone is actually the better choice for PN pain.
It is a NMDA antagonist. The NMDA receptors are responsible for pain transmission.

http://en.wikipedia.org/wiki/Methadone

Methadone is less abuseable, and does not cause the euphoria that other opiates do.

Its downside is that for people susceptible to long QT syndrome it can be dangerous. QT is a heart rhythm problem. It can be induced by some drugs, genetics and/or dehydration with low potassium and magnesium. So it should be monitored carefully and not increased suddenly.
No pharmacist who knows about drugs should give you any "looks" or hassles about methadone.
Methadone is the only opiate that causes this side effect.

my thread:
http://neurotalk.psychcentral.com/thread1120.html
post #4
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