Let's talk about those 'meaningless'
antigliadin IgG antibodies. I know we have done this before, but sadly, its no longer accessible.
What I'd like to do is find references of various conditions where AGA positivity is found, particularly AGA IgG.
Gluten related neurological disease:
Gluten sensitivity as a neurological illness, M Hadjivassiliou, et al.
Neuropathy associated with gluten sensitivity. PMID: 16835287 July 2006
I believe I have read about antigliadin IgG antibodies seen in these conditions, but I would like to track down some references. If anyone knows or finds anything, please post!
Crohn's Disease
High prevalence of celiac disease among patients affected by Crohn's disease. PMID: 15973121 July 2005
Diabetes
We found a significantly higher occurrence of gliadin antibodies in LADA patients: the rate of AGGAb was 19.1% in comparison with 3.5% in the T2DM group (P = 0.0026), the rate of AGAAb was 13.2% in comparison with 3.5% (P = 0.035). The prevalence of EMAb was very low in both groups (1.5% and 0).
Gliadin, endomysial and thyroid antibodies in patients with latent autoimmune diabetes of adults (LADA). PMID: 12823288 July 2003
[Risk markers for insulin-dependent diabetes mellitus and duration of exposure to gluten in celiac patients] PMID: 15478300 Aug 2004
Down Syndrome
Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies.
PMID: 9001668 Dec 1996
Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. PMID: 9445503 Feb 1998
IgA Deficiency
Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. PMID: 15571003 Nov 2004
Irritable Bowel Syndrome
The mechanism by which food activates mucosal immune system is uncertain, but food specific IgE and
IgG4 appeared to mediate the hypersensitivity reaction in a subgroup of IBS patients. Exclusion diets based on skin prick test, RAST for IgE or
IgG4, hypoallergic diet and clinical trials with oral disodium cromoglycate have been conducted, and some success has been reported in a subset of IBS patients.
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. PMID: 16918724 Aug 2006
Determination of the level of specific markers of celiac disease (in our research--antigliadin Ig) is considered to be the optimal method of diagnostic celiac disease in this group of patients.
[Prevalence of undiagnosed celiac disease in patients with irritated bowel syndrome] Oct 2003
Liver Disease
Antigliadin antibody classes in chronic liver disease. PMID: 1421449 Oct 1992
MS
Results - Highly significant increases compared with controls were found for IgA and IgG antibodies against gliadin and gluten. IgA antibodies against casein were significantly increased. Anti-endomycium and anti-transglutaminase antibodies were negative.
IgA antibodies against gliadin and gluten in multiple sclerosis. PMID: 15355487 Oct 2004
Psoriasis
Coeliac disease-associated antibodies correlate with psoriasis activity. PMID: 15491433 Oct 2004
[The significance of diet and associated factors in psoriasis.] PMID: 16758223 June 2006
Rheumatoid Arthritis
[Antigliadin antibodies in rheumatoid arthritis] PMID: 8293004 Mar 1993
Gliadin immune reactivity in patients with rheumatoid arthritis. PMID: 8575138 Sept 1995
Schizophrenia
Autoantibodies associated with psychiatric disorders. PMID: 16719797 May 2005
[could not find anything specific to antigliadin antibodies...but several newer studies looking at schizophrenia as an immune mediated disease]
The gluten connection: the association between schizophrenia and celiac disease. PMID: 16423158 Feb 2006
SLE
Gluten sensitivity masquerading as systemic lupus erythematosus Feb 2004
More schizophrenics than controls showed IgA antibody levels above the upper normal limit to gliadin, beta-lactoglobulin, and casein. [do you suppose they looked for antigliadin IgG antibodies? jcc]
Specific IgA antibody increases in schizophrenia. PMID: 7772650 Mar 1995
Sjogren's
Even among nonceliac patients with primary Sjogren's syndrome, an ongoing inflammation is often present in the small bowel mucosa.
Celiac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome. PMID: 10201480 April 1999
Thyroid disease
The presence of the antigliadin antibodies in autoimmune thyroid diseases. PMID: 15244201 Dec 2003
Ulcerative Colitis
High frequency of antigliadin antibodies and absence of antireticulin and antiendomysium antibodies in patients with ulcerative colitis. PMID: 10204612 Feb 1999