Just registered and don't know etiquitte of site, but expect it's an individual thing based on each individual's condition. I'm almost 5 years since onset and work in an office, and did accept a demotion 2 years ago from management position in attempt to reduce stress and workload with limited success. Appointment tomorrow with company doctor to discuss accommodations under ADA...flexible work schedule, longer breaks to take mid-day nap, and hopefully be able to work from hom periodically. There definitely have been times when I thought I'd have to go on disability but hopefully only 6 more years to retirement (if able to afford to retire after the global meltdown) so I take it day to day and celebrate each completed year towards that retirement goal. Not easy but a lot of determination.