Hi Erin, I'll chime in here...had a lot of experience with PICC and central lines.

There should be no pain aside from some at the insertion site, and by now that should be gone..The fact that they didnt' have time for you is disheartening. You're an immunosuppressed patient, stuff like that is important.

Things like this should be looked into early. I'd call your GP and have them scope it out or go back to wherever you get it flushed and have it evaluated.

This is for sure a good example of that old saying, better to be safe then sorry. I hope you're doing good under the circumstances : / stay in touch and let us know what happens!