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Old 03-20-2009, 10:48 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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Quote:
Originally Posted by Jaspar View Post
A family member was off all supplements for about 10 days before testing levels. They found very high B12 & folate . We were told it meant a metabolic problem causing kidneys to have to hang on to all the B12 & folate they could because the CELLS still needed more.

DNA tests showed genetic variants hindering utilizaion of B12 and Folate (which would also mess up the whole mitochondrial energy production cycle using glycine etc).

The net of it is that in spite of the high blood levels, the family member is on Metanx (methylated B12, methylated folate and p-5-p).
That sounds like one the 25 polymorphism DNA errors in the methylation metabolic sequence. This is called MTHFR mutation

The Metanx has all 3 vitamins activated so the body does not have to do it.
This is one reason I recommend methylcobalamin rather than cyano form.
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