Mrsd is correct. Use of the two compounds can produce Serotonin Syndrome.

Amitriptyline inhibits the metabolism of the main component of tramadol which is an SSRI. No, tramadol is NOT an antidepressant, but it contains a serotonin reuptake inhibitor, which boosts the synthetic opiate in the drug. The drug is technically an opiate agonist. The combination of the two comes up as a potential for severe interaction on the medical data base drug checker I have access to. I would consult with your physician before increasing the dose.

Amitriptyline uses the same enzymatic pathway in the liver to clear itself from the body, and it also inhibits this enzyme from clearing tramadol. More information can be found by googling Cytochrome P450.

It appears that 400mg is the dose maximum.

Serotonin Syndrome is the issue. You can have too much serotonin in your system.

Finding the right cocktail of meds for neuropathy or any painful condition should include your doc.

There is no interaction found for gabapentin and tramadol, other than the maximum dose of 400mg daily.

Tramadol is not a benign pain reliever by any means. It should be used as prescribed.

Here is another link regarding Tramadol (Ultram)

http://www.opioids.com/tramadol/index.html

I hope you are able to find something to help the pain. Please get in contact with your physician.