Raises my hand...same here. When I was first diagnosed the ON was severe and sudden and I didn't know anything about IVSM, so I did as I was told. They forgot to tell me about the side effects!

I didn't like being up for 80+ hours, the horrible rage that would sweep over me without warning for no good reason, the stomach thing, etc.

Three months later, another round for another relapse. I made it through two of three infusions and that was it.

Three months later...oral prednisone.

After that if it wasn't a severe relapse I just called and let the doc know what was going on and refused the steroids until the month before I went on Tysabri when the new neuro convinced me that I needed another course of steroids and I did a three day high dose run of oral pred again.

That was in May 2007 and I am hoping I never have to do them again!