I wonder if you were on antibiotics before this motor neuropathy manifested? Cipro or Levaquin, or Avelox?
I think you might benefit from acetyl carnitine. It works with ALA and improves mitochondria functions.
There is an improved version of ALA now called r-lipoic acid.
It is much more potent, in a lower dosage. Typically 100mg a day is enough. ALA itself requires high doses to work because some of it is inactive.
Another useful supplement is benfotiamine which is a version of thiamine.
Quote:
Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.Click here to read Links
Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro.
Schmid U, Stopper H, Heidland A, Schupp N.
Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
BACKGROUND: Complications in diabetes mellitus are partially mediated by enhanced formation of reactive oxygen species. Among the factors involved in reactive oxygen species formation, advanced glycation end products play a key role. Owing to a reduced activity of the enzyme transketolase, which requires diphosphorylated thiamine (vitamin B(1)) as cofactor, an accumulation of those deleterious glucose metabolites especially in diabetic patients can be observed. Benfotiamine, a lipophilic thiamine diphosphate prodrug, prevented early renal and retinal changes in animal studies, and reduced neuropathic pain in clinical studies. Several mechanisms for these activities have been described. We investigated for the first time direct antioxidant abilities of benfotiamine. Additionally, a potential DNA protective effect of benfotiamine was analysed. METHODS: Oxidative stress was detected by flow cytometry, antioxidative capacity was measured with the ferric reducing ability of plasma (FRAP) assay, two endpoints for genomic damage were assessed: the comet assay and the micronucleus test, and the expression and activity of transketolase was quantified. RESULTS: Benfotiamine prevented oxidative stress induced by the mutagen 4-nitroquinoline-1-oxide (NQO), the uremic toxin indoxyl sulfate, and the peptide hormone angiotensin II in three different kidney cell lines. Cell-free experiments showed a direct antioxidant effect of benfotiamine, which might account for the protective effect. Oxidative DNA damage, induced by angiotensin II, was completely prevented by benfotiamine. Incubation with benfotiamine increased transketolase expression and activity in the cells. CONCLUSIONS: Benfotiamine shows a direct antioxidant action. This effect of benfotiamine may be involved in the improvement of diabetic late complications, including peripheral neuropathy.
PMID: 18384109 [PubMed - indexed for MEDLINE]
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from
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
I hope your dose of B12 is adequate..at least 1000mcg/day and preferably the methyl version.
There is an RX version of methyl B12/ activated B6 and activated folate called Metanx made for neuropathy. This may be very helpful for you.
Many regular vitamins are not in the active state when put into supplements. Some people lack the biological ability to convert them, so they suffer deficiency in the face of plenty.
Metanx is designed to help those. Your young age and progression suggest a unique problem you may have.
Genetic polymorphisms in methylation chemistry are inherited and can be treated more effectively by choosing ACTIVATED forms for the vitamins involved.
More here:
http://www.metanx.com/
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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